This study aims to analyse how different types of aerobic exercise can influence cardiovascular health and the levels of a protein called BDNF, which is related to brain function and cardiac recovery, in patients with Coronary Artery Disease. Three training modalities will be compared: high‑intensity exercise with long intervals, high‑intensity exercise with short intervals, and moderate‑intensity continuous training. In addition, the study will examine whether factors such as sex, baseline physical fitness, and specific genetic characteristics may influence the outcomes.
Total of 252 participants will be recruited, half of them women. Before starting the training programme, their vascular health, physical capacity, and blood BDNF levels will be assessed, both at rest and after exercise. Participants will then be randomly assigned to one of the three training modalities and will complete sessions three times per week over two periods of six weeks each.
At the end of each period, the tests will be repeated to measure changes in vascular health, physical capacity, and BDNF levels. In addition, during the third week, the study will assess how a single exercise session affects these levels. Based on these results, the aim is to identify which type of exercise is most beneficial for people with Coronary Artery Disease and how different factors may influence its effectiveness.
